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KMID : 0829220110350020101
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Korean Journal of Oral and Maxillofacial Pathology
2011 Volume.35 No. 2 p.101 ~ p.106
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Immunohistochemical Characteristics of Central Granular Cell Odontogenic Tumor
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Kwon Tae-Geon
Jung Jae-Kwang
Park Eui-Kyun
Shin Hong-In
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Abstract
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The central granular cell odontogenic tumor is a rare benign odontogenic neoplasm of uncertain hisotogenesis characterized by varying amounts of eosinophilic granular cells and apparently inactive odontogenic epithelium with variable presence of calcified tissue. We present a case of central granular cell odontogenic tumor involving the maxilla of 35-year-old man with immunohistochemical characterization of granular cells. In microscopic view, the granular cells densely packed in sheets and lobules with abundant eosinophilic, granular cytoplasm and eccentric round-to-ovoid nuclei revealed immunoreactivity for vimentin, α1-antitrysin and CD68, and NSE but not for cytokeratin and S-100 protein while the interspersed odontogenic epithelial cells were positive for cytokeratin only. Granular cells also revealed strong PAS staining. Numerous concentric structured round to ovoid calcified aggregates were also noted. The lesion was treated with excision without recurrence for 8 years. Our immuohistochemical staining findings also suggest that the granular cells of central granular cell odontogenic tumor are mesenchymal in origin with possible histiocytic differentiation.
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KEYWORD
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Calcification, Granular cells, Immunohistochemistry, Odontogenic tumor
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